EXPERT RETINOL RX™ 2% RETI-JECTION™ SERUM
Infused with 2% Retinol RX™ and retinol-infused spicules, this serum delivers professional collagen booster treatment–level efficacy, helping skin appear smoother, firmer, and visibly revitalized.¹
Dull Skin · Loss of Firmness · Visible Pores · Fine Lines · Wrinkles

⠀
¹Instrumental results from a split-face study in 32 participants; 2 cc collagen booster treatment vs. product used twice daily for 4 weeks. Parameters including firmness, wrinkles, pores, radiance and volume.

WHAT IS RETINOL RX™ 2%
RETI-JECTION™ SERUM?
Retinol RX™ Reti-jection Serum is engineered to deliver collagen booster treatment–level results, demonstrated in a split-face clinical study¹.
This efficacy is powered by the synergy of IOPE’s proprietary retinol formulation and micro needle–like spicule technology, designed to support enhanced absorption and optimized delivery.
Ideal for those who have not seen visible results from retinol, or who are concerned with fine lines, loss of firmness, and enlarged pores.

INNOVATIVE DELIVERY TECHNOLOGY POWERED BY 3 MILLION
RETINOL-INFUSED SPICULES²
Spicules are ultra-fine, microneedle-like particles that enhance absorption and refine the skin surface, creating a mild tingling sensation.
IOPE advances this technology by infusing retinol directly into the spicules, enabling more efficient delivery. In a clinical study, the serum demonstrated 46% enhanced absorption compared to spicule-free formulations.
Despite its high-performance efficacy, the sensory remains gentle. IOPE softened and polished the edges of the spicules, reducing irritation by 80%³ while enhancing skin comfort for a smoother application experience.

MEDICALLY INSPIRED
IOPE's PROPRIETARY ADVANCED FORMULATION, RETINOL RX™
Backed by 30 years of retinol research, IOPE has developed ways to enhance retinol efficacy while helping reduce irritation.
Traditional retinol typically undergoes several conversion steps before becoming active in the skin. IOPE’s Retinol RX™ is designed to become active without additional conversion, helping maintain consistent efficacy while improving skin tolerability.
This serum features a 2% concentration of Retinol RX™, enhanced with IOPE’s spicule technology to support optimized delivery. With continued use, wrinkles appear reduced and deeper signs of aging look visibly improved.
VISIBLE IMPROVEMENTS IN
LINES & WRINKLES


AFTER
4 WEEKS⁴
agree skin felt firm
agree pores appeared tighter
agree fine lines looked reduced

HOW TO USE
STEP 1
Cleanse skin and apply toner.
STEP 2
Apply a full pump to full face at night.
STEP 3
Always wear sunscreen during the day.
RETINOL ASSORTMENT

PROFESSIONAL-LEVEL
ANTI-AGING RETINOL ROUTINE
STEP 1
Retinol RX™ 1% Serum
Low-irritation daytime firming care
STEP 2
Retinol RX™ 2% Serum
Intensive nighttime care for collagen booster efficacy
STEP 3
Retinol Hydrogel Mask
Lock-in Booster Mask for amplified retinol synergy
¹ Instrumental results from a split-face study in 32 participants; 2 cc collagen booster treatment
vs. product used twice daily for 4 weeks. Parameters including firmness, wrinkles, pores,
radiance, and volume.
² Average number of spicule based on 30 mL / 1.01 fl. oz. (full-sized product).
³ Sensory evaluation (n=31): 0.5% Reti-jection spicule cream vs. 0.5% hydrolyzed sponge spicule cream, stinging and burning assessed over 9 minutes.
⁴ Self-assessment from clinical, 32 participants, used 2x daily for 4 weeks.



